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In the study, researchers administered small doses of sildenafil to hamsters before adjusting the cycles of light and dark they lived in. This reset their body clocks as if they'd taken a six-hour plane trip to the east.
Erectile dysfunction (ED, "male impotence") is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis sufficient for satisfactory sexual performance.
Reduced sperm count in also found due to the excessive stress and is found to one of reasons for the unsatisfactory sex life.
By increasing the intracellular concentrations of cyclic guanosine monophosphate (cGMP), phosphodiesterase-5 (PDE5) inhibitors such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) have been used therapeutically to treat erectile dysfunction (12), pulmonary hypertension (13), and cardiac hypertrophy (14). More recently, they were shown to induce apoptosis in different human tumors such as colon carcinoma and chronic lymphocyte leukemia (15, 16). In our mouse models, we show that pharmacologic PDE5 blockade down-regulates MDSC suppressive pathways and restores antitumor immunity. Moreover, our in vitro experiments using PBMCs from multiple myeloma (MM) and head and neck cancer patients suggest that the same mechanisms found in mice are also present in humans and demonstrate a possible role for PDE5 inhibitors as an immune adjuvant in the clinical setting.
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Erectile dysfunction takes more than a physical toll. The emotional impact the condition can have on a man and his partner can be just as difficult. It is common for men with ED to feel anger, frustration, sadness, or lack confidence. However, the condition can be treated. The first step in addressing your concerns about ED is to be honest with yourself, your partner, and your doctor. Once ED has been brought out into the open, coping with it as you go through treatment will be easier and less stressful. Communication is essential to a successful diagnosis and treatment, as well as, helping your partner understand your feelings.
FRIDAY, Sept. 18 (HealthDay News) -- A topical cream for erectile dysfunction shows promise in animal testing and could become an alternative for men who can't tolerate the pill form of the drugs, U.S. researchers report.
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The hamsters recovered 25 percent to 50 percent more quickly from the equivalent of human jet lag, needing less time to synchronize themselves to the new schedule, said Dr. Diego Golombek, a researcher with the Universidad Nacional de Quilmes in Buenos Aires. He said sildenafil worked at least as well as melatonin, a jet-lag treatment.
An erection starts in the brain, where arousal signals trigger a chemical chain reaction. This process results in relaxation of the muscle in the blood vessel walls that keeps blood from flowing into the penis. Lots of different things can go wrong along the way, which is why there are so many different causes of ED.
The review, which covers more than fifty studies published between 1995 and 2009, provides a valuable overview of the scale of counterfeit internet drugs, with a specific focus on erectile dysfunction (ED) drugs.
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Drugs (Anti-depressants (SSRIs) and Nicotine are most common. A study entitled “Drug-induced male sexual dysfunction” concluded that of the 12 most commonly prescribed medications on the market today, 8 of those medications list “impotence” as a side-effect of the drug. Other drugs such as alcohol, cocaine, and heroin negatively impact male sexual libido.)
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Italian researchers report that laboratory studies show that the compound has the potential to treat erectile dysfunction, and possibly with fewer side effects than its pharmaceutical cousin.
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